Fournette did not practice all week but said Thursday that he believed he would be able to play.
He is second in the league in rushing (596 yards) and carries (130) and also has 15 catches for 136 yards. He accounts for 36 percent of the Jaguars’ total offensive yardage.
Chris Ivory, who has 162 yards on 40 carries and 16 catches for 143 yards, will start.
T.J. Yeldon, the Jaguars’ second-round pick in 2015, will be active for the first time this season.